<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019df578-8f28-7d49-8fbb-e3bf372dbb2d,g:58288f4d-7eb1-447e-aabd-38387369369e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://spyglasspharma.com/role/Cover" xlink:type="simple" xlink:href="sgp-20260514.xsd#Cover"/>
  <link:presentationLink xlink:role="http://spyglasspharma.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019df578-8f28-7bb7-a250-6d603882b868" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_DocumentType_019df578-8f28-7bb7-a250-6d603882b868" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019df578-8f28-7735-a9f6-bc8e3648e71c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_DocumentPeriodEndDate_019df578-8f28-7735-a9f6-bc8e3648e71c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019df578-8f28-71e4-836a-450f3dbdc3f4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityRegistrantName_019df578-8f28-71e4-836a-450f3dbdc3f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019df578-8f28-76a8-b8dd-f02da7db73c0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019df578-8f28-76a8-b8dd-f02da7db73c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019df578-8f28-77c4-b28f-77f42dd0ffa8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityFileNumber_019df578-8f28-77c4-b28f-77f42dd0ffa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019df578-8f28-7f6b-920a-a1e3b1e30adf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityTaxIdentificationNumber_019df578-8f28-7f6b-920a-a1e3b1e30adf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019df578-8f28-7968-b582-29a21d422c77" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityAddressAddressLine1_019df578-8f28-7968-b582-29a21d422c77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019df578-8f28-78b7-976c-0eccab16476d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityAddressAddressLine2_019df578-8f28-78b7-976c-0eccab16476d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019df578-8f28-70a9-9ee6-b4338e808687" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityAddressCityOrTown_019df578-8f28-70a9-9ee6-b4338e808687" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019df578-8f28-700d-9749-49783806fba2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityAddressStateOrProvince_019df578-8f28-700d-9749-49783806fba2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019df578-8f28-7bc1-8451-2c725fbb2a36" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityAddressPostalZipCode_019df578-8f28-7bc1-8451-2c725fbb2a36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019df578-8f28-781c-8bb4-18f03b081d11" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_CityAreaCode_019df578-8f28-781c-8bb4-18f03b081d11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019df578-8f28-78c7-8436-be15c61f9af0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_LocalPhoneNumber_019df578-8f28-78c7-8436-be15c61f9af0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019df578-8f28-7fb3-95cb-b7955f11e88f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_WrittenCommunications_019df578-8f28-7fb3-95cb-b7955f11e88f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019df578-8f28-713e-8f4e-ff462c726f9f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_SolicitingMaterial_019df578-8f28-713e-8f4e-ff462c726f9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019df578-8f28-70dd-8918-91acc5c48e43" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_PreCommencementTenderOffer_019df578-8f28-70dd-8918-91acc5c48e43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019df578-8f28-72d1-8386-eea2f70ad8f6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019df578-8f28-72d1-8386-eea2f70ad8f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019df578-8f28-7fa9-b096-6b991179f987" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_Security12bTitle_019df578-8f28-7fa9-b096-6b991179f987" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019df578-8f28-7b22-9718-8acde673161e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_TradingSymbol_019df578-8f28-7b22-9718-8acde673161e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019df578-8f28-7a36-9172-5b43f302cc45" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_SecurityExchangeName_019df578-8f28-7a36-9172-5b43f302cc45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019df578-8f28-7cba-9ac6-c698eec78cad" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityEmergingGrowthCompany_019df578-8f28-7cba-9ac6-c698eec78cad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_019df578-8f28-7e1c-9d4b-0cf2796c04d5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityExTransitionPeriod_019df578-8f28-7e1c-9d4b-0cf2796c04d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019df578-8f28-74c8-9837-0b789070efbc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_EntityCentralIndexKey_019df578-8f28-74c8-9837-0b789070efbc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019df578-8f28-7238-860a-544f267e2336" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019df578-8f28-7c97-8f7d-7bad872614a8" xlink:to="loc_dei_AmendmentFlag_019df578-8f28-7238-860a-544f267e2336" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
